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Article

Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31).

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2019

Ishikawa Kinya, Nagai Yoshitaka

Abstract excerpt

Spinocerebellar ataxia type 31 (SCA31) is one of the autosomal-dominant neurodegenerative disorders that shows progressive cerebellar ataxia as a cardinal symptom. This disease is caused by a 2.5- to 3.8-kb-long complex pentanucleotide repeat containing (TGGAA)n, (TAGAA)n, (TAAAA)n, and (TAAAATAGAA)n in an intron of the gene called BEAN1 (brain expressed, associated with Nedd4). By comparing various...

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PMID: 31755042
DOI: 10.1007/s13311-019-00804-6
PMCID: PMC6985187

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