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Article

Superoxide Dismutase SOD1, Encoded on Chromosome 21, but Not SOD2 is Overexpressed in Brains of Patients with down Syndrome

1 Jan 2001

Abstract excerpt

BACKGROUND: The antioxidant enzyme Cu/Zn-superoxide dismutase-1 (SOD1) gene is localized to chromosome 21q22.1 and catalyzes the dismutation of superoxide anions to hydrogen peroxide, which may lead to the increased production of active oxygen species in Down Syndrome (DS), trisomy 21. Although a number of studies have addressed this question, proposing the overexpression hypothesis, no specific protein-chemical...

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Identifiers

PMID: 11217146
DOI: 10.2310/6650.2001.34089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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