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The central nervous system is a potential reservoir and possible origin of drug resistance in HBV

2023-04-07

Abstract excerpt

<h4>ABSTRACT</h4> The significance of HBV in cerebrospinal fluid (CSF) is unclear. In the present study, s ynchronous serum and CSF samples were collected from 13 patients. HBV-DNA, full-length genome, quasispecies, phylogenetic tree, compartmentalization and mutation of reverse transcriptase (RT) region analyses were performed based on PCR and sequencing methods. We found HBV-DNA was detected in the CSF of 3 an...

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Literature Corpus work
f14d6b26-02e8-561a-aa1b-bd90b1aa70ec
DOI
10.1101/2023.04.05.535804
Open publication

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