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Article

Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model.

Molecular neurobiology - 1 Jun 2021

Mollá Belén, Heredia Miguel, Sanz Pascual

Abstract excerpt

Lafora disease (LD; OMIM#274780) is a fatal rare neurodegenerative disorder characterized by generalized epileptic seizures and the presence of polyglucosan inclusions (PGs), called Lafora bodies (LBs), typically in the brain. LD is caused by mutations in two genes EPM2A or EPM2B, which encode respectively laforin, a glucan phosphatase, and malin, an E3-ubiquitin ligase. Much remains unknown about the molecular...

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Identifiers

PMID: 33447969
DOI: 10.1007/s12035-021-02285-1
PMCID: PMC8167455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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