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Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance Evaluation

2026-06-30

Abstract excerpt

The Next Generation Impactor (NGI) is one of the regulatory gold standards for characterizing aerodynamic particle size distributions (APSDs) of orally inhaled drug products (OIDPs); however, its reliance on complex, resource-intensive in vitro testing under tightly controlled environmental conditions limits experimental flexibility and introduces variability. In alignment with the growing regulatory emphasis on...

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Literature Corpus work: f0cc602d-3d63-57ed-8c8b-bb6f7880b35d
DOI: 10.64898/2026.06.29.735263

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Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance EvaluationDOI 10.64898/2026.06.29.735263Read

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