Article

Experimental and Computational Analysis of pMDI Aerosol Transport in Pediatric Airways: Impact of Inhalation Flow, Mucus Rheology, and Actuation Timing

2025-06-11

Abstract excerpt

<title>Abstract</title> <p>Effective drug delivery to the lungs of pediatric patients using pressurized metered-dose inhalers (pMDIs) requires a deep understanding of airflow and particle transport within the airways. This study examines airflow patterns and aerosol deposition in a pediatric mouth-throat (MT) model, incorporating a cystic fibrosis (CF) inhalation profile and simulating the presence of a mucus lay...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19075ea9-3773-5671-b00a-157b7484daef
DOI: 10.21203/rs.3.rs-6785337/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Experimental and Computational Analysis of pMDI Aerosol Transport in Pediatric Airways: Impact of Inhalation Flow, Mucus Rheology, and Actuation TimingDOI 10.21203/rs.3.rs-6785337/v1Read

Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung modelSemantic proximity Read

Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance EvaluationSemantic proximity Read

Towards More Precise Targeting of Inhaled Aerosols to Different Areas of the Respiratory SystemSemantic proximity Read

Computational Fluid Dynamic Models as Tools to Predict Aerosol Distribution in Tracheobronchial AirwaysSemantic proximity Read

Computational Fluid Particle Dynamics-Informed Machine Learning Prototype for a User-Centered Smart Inhaler Enabling Uniform Drug Delivery to Small AirwaysSemantic proximity Read

Personalized Inhaler Selection in COPD and Asthma: Clinical Implications of Aerosol Characteristics and Device PerformanceSemantic proximity Read

Towards a Customized Oral Drug Therapy for Pediatric Applications: Chewable Propranolol Gel Tablets Printed by an Automated Extrusion-Based Material Deposition MethodSemantic proximity Read

Dose Emission and Aerodynamics Characterization of Tiotropium Particles Are Influenced by the Inhalation Rate and Number of Inhalations Per Inhaler DoseSemantic proximity Read

Open-source 3D printed manifolds for exposure studies using human airway epithelial cellsSemantic proximity Read

Intranasal and Pulmonary Lipid Nanoparticles for Gene Delivery: Turning Challenges into OpportunitiesSemantic proximity Read

A General High-throughput Mucus Microrheology Platform For Personalized MedicineSemantic proximity Read

Experimental Evaluation of Dry Powder Inhalers During In- and Exhalation Using a Model of the Human Respiratory System (xPULM™)Semantic proximity Read