Article

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection

2020-12-28

Abstract excerpt

<h4>SUMMARY</h4> SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood. Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when repr...

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Literature Corpus work: f0c4b3be-3260-5a22-b325-efe20704c561
DOI: 10.1101/2020.12.28.424554

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