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ACE2 decoy Fc-fusions and bi-specific killer engager (BiKEs) require Fc engagement for <i>in vivo</i> efficacy against SARS-CoV-2

2024-06-21

Abstract excerpt

SARS-CoV-2 virus has continued to evolve over time necessitating the adaptation of vaccines to maintain efficacy. Monoclonal antibodies (mAbs) against SARS-CoV-2 were a key line of defense for unvaccinated or immunocompromised individuals. However, these mAbs are now ineffective against current SARS-CoV-2 variants. Here, we tested three aspects of αSARS-CoV-2 therapeutics. First, we tested whether Fc engagement is...

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Literature Corpus work: 9b4dfc63-fcb1-5232-b1b0-038811e8acdc
DOI: 10.1101/2024.06.20.599956

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ACE2 decoy Fc-fusions and bi-specific killer engager (BiKEs) require Fc engagement for <i>in vivo</i> efficacy against SARS-CoV-2DOI 10.1101/2024.06.20.599956Read

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