Development of a Flexible Multiplex Urine RNA Assay for Detection and Differentiation of Kidney Allograft Injury

Abstract excerpt

<h4>ABSTRACT</h4> Non-invasive approaches to detect kidney graft injury and distinguish donor-specific immune-mediated injury from other causes of inflammation are needed to guide recipient therapy while avoiding the morbidities of transplant biopsies. We used a multi-plex platform to interrogate RNA isolated from kidney transplant recipient urine to investigate gene expression patterns distinguishing grafts with...

Topics

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• Algorithms
• Biopsy
• Cell-Free Nucleic Acids
• Cytomegalovirus and herpesvirus research
• Graft Rejection
• Organ Donation and Transplantation
• Organ Transplantation Techniques and Outcomes
• Renal Transplantation Outcomes and Treatments

Identifiers and source

Literature Corpus work

f04f0c2b-a75e-532f-a066-5df86b7c16c1

DOI

10.1101/2025.08.25.25334374