Article

Cell culture system to efficiently test candidate genes and molecular pathways implicated in congenital diaphragmatic hernias

2020-04-04

Abstract excerpt

<h4>ABSTRACT</h4> The mammalian muscularized diaphragm is essential for respiration and defects in the developing diaphragm cause a common and frequently lethal birth defect, congenital diaphragmatic hernia (CDH). Human genetic studies have implicated more than 150 genes and multiple molecular pathways in CDH, but few of these have been validated because of the expense and time to generate mouse mutants. The pleu...

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Literature Corpus work: f047fa3b-e3c0-5b59-95fd-f783c09b0e8a
DOI: 10.1101/2020.04.03.024851

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