Article
Abnormal lung development in congenital diaphragmatic hernia.
Seminars in pediatric surgery - 1 Jun 2017
Ameis Dustin, Khoshgoo Naghmeh, Keijzer Richard
Abstract excerpt
The outcomes of patients diagnosed with congenital diaphragmatic hernia (CDH) have recently improved. However, mortality and morbidity remain high, and this is primarily caused by the abnormal lung development resulting in pulmonary hypoplasia and persistent pulmonary hypertension. The pathogenesis of CDH is poorly understood, despite the identification of certain candidate genes disrupting normal diaphragm and...
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