Article

A Deletion Variant of Human Factor VIII Displaying Low Immunogenicity in a Murine Model of Hemophilia A

2025-10-03

Abstract excerpt

The therapeutic clotting factor VIII (FVIII) is known for its particular immunogenicity, with nearly 30% of the hemophilic patients developing neutralizing antibodies against the infused protein. The root cause of this immunogenicity is still not well understood, but intrinsic factors, such as FVIII by-products, have been linked to the immunological response elicited. Bioengineering of the FVIII molecule has been...

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Literature Corpus work: f027b7f5-4ba1-51da-bcaa-13acb44a39cc
DOI: 10.20944/preprints202510.0290.v1

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