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The causal connections between gut microbiota and chronic pain and pain phenotypes through the gut-brain axis: A Mendelian randomization study and mediation analysis

2024-09-30

Abstract excerpt

Recent studies have increasingly highlighted a potential link between gut microbiota (GM) and chronic pain. However, existing research has yielded mixed results, leaving many questions unanswered. We employed a two-sample Mendelian randomization design to investigate whether GM directly influences multisite chronic pain (MCP) and eight phenotypes. We then used a combination of meta-analysis, genetic colocalization...

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Literature Corpus work
effe24f9-de43-5412-ac47-f222b21e7bd9
DOI
10.1101/2024.09.28.24314553
Open publication

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The causal connections between gut microbiota and chronic pain and pain phenotypes through the gut-brain axis: A Mendelian randomization study and mediation analysisDOI 10.1101/2024.09.28.24314553
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