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Article

Genetically predicted the causal relationship between gut-brain axis and chronic pain: a Mendelian randomization study.

Human genomics - 11 Dec 2025

Shi Shaopeng, Zhou Xinyu, Ma Chunxiang, Wang Yi, Deng Geng, Ma Wan

Abstract excerpt

BACKGROUND: Although previous studies have indicated a potential association between gut–brain axis dysfunction and chronic pain, the causal relationship and underlying pathogenic mechanisms remain unclear. Therefore, this study employed Mendelian Randomization (MR) analysis to investigate the causal effect of the gut–brain axis on chronic pain from a genetic perspective. METHODS: This study utilized the largest...

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PMID: 41382250
DOI: 10.1186/s40246-025-00876-w
PMCID: PMC12781469

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