Article

Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

2021-05-17

Abstract excerpt

Profound endothelial dysfunction accompanies the microvascular thrombosis commonly observed in severe COVID-19. In the quiescent state, the endothelial surface is anticoagulant, a property maintained at least in part via constitutive signaling through the Tie2 receptor. During inflammation, the Tie2 antagonist angiopoietin-2 (Angpt-2) is released from activated endothelial cells and inhibits Tie2, promoting a prot...

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Literature Corpus work: efdf0971-9c4b-522d-869c-5ff8076a01b1
DOI: 10.1101/2021.05.13.21257070

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