Article

Genetically encoded multimeric tags for intracellular protein localisation in cryo-EM

2022-12-10

Abstract excerpt

Cryo-electron tomography is a powerful label-free tool for visualizing biomolecules in their native cellular context at molecular resolution. However, the precise localisation of biomolecules of interest in the tomographic volumes is challenging. Here, we present a tagging strategy for intracellular protein localisation based on genetically encoded multimeric particles (GEMs). We show the applicability of drug-con...

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Identifiers and source

Literature Corpus work: ef2f024b-111c-56ea-99ce-78ca3e5c01c4
DOI: 10.1101/2022.12.10.519870

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