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Small-Molecule Antagonist of VLA-4 (GW559090) Attenuated Neuro-Inflammation by Targeting Th17 Cell Trafficking across the Blood-Retinal Barrier in Experimental Autoimmune Uveitis

2020-09-24

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>The integrin VLA-4 (α4β1) plays an important role in leukocyte trafficking. This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious posterior uveitis (experimental autoimmune uveitis; EAU) and its effect on intraocular leukocyte subsets.<bold>Methods: </bold>Mice<bold> (</bold>female; B10...

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Literature Corpus work: ef0ef0bf-d78b-50e8-90e6-bd9779008d9d
DOI: 10.21203/rs.3.rs-65522/v1

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