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Article

Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva

19 Nov 2018

Abstract excerpt

Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we further evaluated the effects of VPA on post-operative inflammation using the mouse model of conjunctival scarring. VPA, injected into the subconjunctiva immediately after...

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PMID: 30456449
DOI: 10.1007/s00109-018-1722-x

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