Rapid and quantitative analysis of bacteriophage infectivity via fully-automated droplet digital PCR

Abstract excerpt

<title>Abstract</title> <p> The clinical translation of phage therapy for multidrug-resistant (MDR) infections is constrained by the lack of rapid, standardized susceptibility testing methods. Here, we present digital Phage Susceptibility Testing (dPST), an automated droplet digital PCR (ddPCR)-based workflow that directly quantifies phage-induced bacterial DNA release as a universal molecular signature of lysis...

Topics

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• Advanced biosensing and bioanalysis techniques
• Bacteriophages and microbial interactions
• Biosensors and Analytical Detection
• DNA
• Microbial infections and disease research
• Monoclonal and Polyclonal Antibodies Research
• Parasites
• SARS-CoV-2 detection and testing

Identifiers and source

Literature Corpus work

ee4b7b48-66d2-5f95-90b8-55c78d04a159

DOI

10.21203/rs.3.rs-8591046/v1