Back to search

Article

Synthesis and Thrombin, Factor Xa and U46619 Inhibitory Effects of Non-amidino and Amidino <em>N<sup>2</sup></em>-Thiophenecarbonyl- and <em>N<sup>2</sup></em>-Tosylanthranilamides

2017-02-03

Abstract excerpt

Thrombin (factor IIa) and factor Xa (FXa) are key enzymes at the junction of the intrinsic and extrinsic coagulation pathways and are the most attractive pharmacological targets for the development of novel anticoagulants. Twenty non-amidino N2-thiophencarbonyl- and N2-tosyl anthranilamides 1-20 and six amidino N2-thiophencarbonyl- and N2-tosylanthranilamides 21-26 were synthesized and evaluated prothrombin time (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ee1bfd7f-e630-519e-9fa3-c2a9d0506db4
DOI
10.20944/preprints201702.0009.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Synthesis and Thrombin, Factor Xa and U46619 Inhibitory Effects of Non-amidino and Amidino <em>N<sup>2</sup></em>-Thiophenecarbonyl- and <em>N<sup>2</sup></em>-TosylanthranilamidesDOI 10.20944/preprints201702.0009.v1
Ex-vivo antiplatelet effects of oral anticoagulantsSemantic proximity
Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects.Semantic proximity
Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist.Semantic proximity
Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.Semantic proximity
In vitro metabolism of a novel antithrombotic compound, S002-333, and its enantiomers: quantitative cytochrome P450 phenotyping, metabolic profiling and enzyme kinetic studies.Semantic proximity
A new binding assay of von Willebrand factor and glycoprotein Ib using solid-phase biotinylated platelets.Semantic proximity
A [+18RGD] protamine variant for nontoxic and effective reversal of conventional heparin and low-molecular-weight heparin anticoagulation.Semantic proximity
Antithrombotic and Prohemorrhagic Actions of Different Concentrations of Apixaban in Patients Exposed to Single and Dual Antiplatelet RegimensSemantic proximity
Select a neighboring publication to make it the new centre.