Article

Intracerebral hemorrhage induces monocyte TNF signaling that is suppressed by Siponimod (BAF312): a single-cell transcriptomics study in patients

2026-01-27

Abstract excerpt

Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. Therapeutic options remain limited. Here we performed single-cell RNA sequencing and plasma cytokine analysis on peripheral blood samples from ICH patients treated with the immunomodulatory drug BAF312 (Siponimod) or placebo at days 1, 3, and 7 post ICH. In the absence of treatment, th...

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Literature Corpus work: ee1a6bb9-6909-5d28-8120-52ed1fc3ed78
DOI: 10.64898/2026.01.22.26344292

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