Article
Healthy ageing men have normal reproductive function but display germline-specific molecular changes
2019-09-16
Abstract excerpt
Children of older fathers have higher risk for certain diseases. Nevertheless, how ageing specifically affects male germ cells is so far not completely understood. In a cohort of 197 healthy men (18-84 years), we found that semen and reproductive parameters remained normal over six decades. Along with an age-dependent increase in telomere length in sperm (r=0.41, p>0.001), we found accelerated DNA fragmentation, m...
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Identifiers and source
- Literature Corpus work
- edba0b15-56f1-58e6-91d0-e8f87adb03ac
- DOI
- 10.1101/19006221