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Cytological and molecular aspects of the ageing sperm

20 Nov 2018

Abstract excerpt

STUDY QUESTION: Is ageing associated with a decline in semen quality and molecular changes to human sperm? SUMMARY ANSWER: Semen quality declines with advancing age and characteristic molecular changes take place during the ageing process, including increased sperm DNA damage, altered sperm protamination and altered seminal plasma miRNA profile. WHAT IS KNOWN ALREADY: During ageing, the reproductive system is...

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PMID: 30551142
DOI: 10.1093/humrep/dey357

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