Article

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugated butyrate prodrug with enhanced oral bioavailability

2023-04-29

Abstract excerpt

Butyrate, a metabolite produced by commensal bacteria, has been intensively studied for its immunomodulatory effects on various immune cells, including T regulatory cells, macrophages, and dendritic cells. Butyrate’s development as a drug has been limited by its poor oral bioavailability due to its rapid metabolism in the gut, its low potency and thus high dosing, and its foul smell and taste. By simply esterifyin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed929605-8b6e-51fb-94fc-8ec6c04bc641
DOI: 10.1101/2023.04.28.538720

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugated butyrate prodrug with enhanced oral bioavailabilityDOI 10.1101/2023.04.28.538720Read

Injectable butyrate-prodrug micelles induce long-acting immune modulation and suppress autoimmune arthritis in miceSemantic proximity Read

Identification of gut dysbiosis in axial spondyloarthritis patients and improvement of experimental ankylosing spondyloarthritis by microbiome-derived butyrate with immune-modulating functionSemantic proximity Read

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cellsSemantic proximity Read

Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosaSemantic proximity Read

Therapeutic Potential of Butyrate for Treatment of Type 2 DiabetesSemantic proximity Read

Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms.Semantic proximity Read

Microbial metabolite butyrate facilitates M2 macrophage polarization and function.Semantic proximity Read

Effects of butyrylated high amylose maize starch (HAMSB) as an adjuvant for oral immunotherapySemantic proximity Read

Serum albumin-fused interleukin-10 prevents neuroinflammation by promoting immunoregulation in the secondary lymphoid organs and limiting immune cell infiltration in the spinal cordSemantic proximity Read

The effect of butyrate-supplemented parenteral nutrition on intestinal defence mechanisms and the parenteral nutrition-induced shift in the gut microbiotaSemantic proximity Read

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulationSemantic proximity Read

Tributyrin Protects the Colon from DSS-induced ColitisSemantic proximity Read