Article

Soluble TIM-3, likely produced by myeloid cells, predicts resistance to immune checkpoint inhibitors in metastatic clear cell renal cell carcinoma

2024-10-16

Abstract excerpt

<h4>Background and objectives</h4> Immunotherapies targeting PD-1 and CTLA-4 are key components of the treatment of metastatic clear cell renal cell carcinoma (mccRCC). However, they have distinct safety profiles and resistance to treatment can occur. We assess soluble TIM-3 (sTIM-3) in the plasma of mccRCC patients as a potential theranostic biomarker, as well as its source and biological significance. <h4>Method...

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Literature Corpus work: ed82cf2f-adcf-5b57-a389-facb434ab138
DOI: 10.1101/2024.10.15.24315164

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