Back to search

Article

Interplay Between Immune Checkpoint Modulators and the Epithelial-to-Mesenchymal Transition Axis in Clear Cell Renal Cell Carcinoma

2026-04-30

Abstract excerpt

<h4>Background: </h4> /Objectives: Clear cell renal cell carcinoma (ccRCC), the predominant malignant subtype of kidney cancer, is the leading cause of death among renal cell carcinoma patients. Although a subset of ccRCC patients benefit from select immune checkpoint inhibitors (ICIs), prognosis remains poor. While PD-1 and PD-L1 have been extensively studied, the prevalence and distribution of other immune check...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b53ce9e9-c232-5308-b455-29c9b2dd678d
DOI
10.20944/preprints202604.2137.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Interplay Between Immune Checkpoint Modulators and the Epithelial-to-Mesenchymal Transition Axis in Clear Cell Renal Cell CarcinomaDOI 10.20944/preprints202604.2137.v1
The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney CancerSemantic proximity
High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpointsSemantic proximity
Coexpression of LAG-3 and PD-L1 in tumor infiltrating immune cells predicts worse outcome in clear cell renal cell carcinomaSemantic proximity
MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinomaSemantic proximity
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinomaSemantic proximity
Microenvironment-related gene IGLL5 has potential to predict the prognosis of clear cell renal cell carcinomaSemantic proximity
Characterization of a G2M checkpoint-related gene model and subtypes associated with immunotherapy response for clear cell renal cell carcinomaSemantic proximity
Multi-omics features-based machine learning method improve immunotherapy response in clear cell renal cell carcinomaSemantic proximity
Assessing the role of programmed cell death signatures and related gene TOP2A in progression and prognostic prediction of clear cell renal cell carcinomaSemantic proximity
CXCL13-CXCR5 Signaling in CD8⁺ T Cell Recruitment and Lymphoid Immune Organization in Clear Cell Renal Cell CarcinomaSemantic proximity
NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinomaSemantic proximity
Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.