Article

The actin binding protein profilin 1 is critical for mitochondria function

2023-08-07

Abstract excerpt

Profilin 1 (PFN1) is an actin binding protein that is vital for the polymerization of monomeric actin into filaments. Here we screened knockout cells for novel functions of PFN1 and discovered that mitophagy, a type of selective autophagy that removes defective or damaged mitochondria from the cell, was significantly upregulated in the absence of PFN1. Despite successful autophagosome formation and fusion with the...

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Literature Corpus work: ed6d61c1-b6c6-508d-81e7-4a6325fa019f
DOI: 10.1101/2023.08.07.552354

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