Article

A translational transcriptomic signature of vaccine reactogenicity for the evaluation of novel formulations

2025-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Accurately predicting vaccine reactogenicity at the preclinical stage remains a major challenge in vaccine development, as conventional animal studies and in vitro assays capture general inflammation but fail to quantify local or systemic reactogenicity relevant to humans. Using transcriptomic data from the BioVacSafe consortium encompassing seven vaccines and immunostimulants in mice and five l...

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Literature Corpus work: ed283baa-6eca-52ae-a005-0256d3aa8796
DOI: 10.1101/2025.11.20.689650

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