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Article

Plumbagin enhances antimicrobial and anti-biofilm capacities of chlorhexidine against clinical Klebsiella pneumoniae while reducing resistance mutations.

Microbiology spectrum - 3 Oct 2024

Liu Haifeng, Chen Huanchang, Ma Zhexiao, Zhang Ying, Zhang Shihang, Zhao Deyi, Yao Zhuocheng, Zhou Tieli, Wang Zhongyong

Abstract excerpt

With the widespread misuse of disinfectants, the clinical susceptibility of Klebsiella pneumoniae (K. pneumoniae) to chlorhexidine (CHX) has gradually diminished, posing significant challenges to clinical disinfection and infection control. K. pneumoniae employs overexpression of efflux pumps and the formation of thick biofilms to evade the lethal effects of CHX. Plumbagin (PLU) is a natural plant extract that...

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Identifiers

PMID: 39162533
DOI: 10.1128/spectrum.00896-24
PMCID: PMC11448042

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