Article

Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss

2025-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Cisplatin is a widely used and effective anticancer drug. However, it causes permanent sensorineural hearing loss in over 50% of treated patients. There are no FDA-approved therapies to prevent cisplatin-induced hearing loss (CIHL) in adults, highlighting a critical unmet clinical need. Previous studies suggest that statins, commonly prescribed cholesterol-lowering drugs, are associated with red...

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Literature Corpus work: ecfdc584-3acb-5311-9719-c0661337694c
DOI: 10.1101/2025.09.23.678043

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