IIAEK Targets Intestinal Alkaline Phosphatase (IAP) to Improve Cholesterol Metabolism with a Specific Activation of IAP and Down-Regulation of ABCA1

Abstract excerpt

IIAEK (Ile-Ile-Ala-Glu-Lys, lactostatin) is a novel pentapeptide from bovine milk β-lactoglobulin which lowers cholesterol levels. However, the molecular mechanisms underlying the suppression of intestinal cholesterol absorption by IIAEK are unknown. Therefore, we evaluated the effects of IIAEK on intestinal cholesterol metabolism in Caco-2 cells in a human intestinal model. We found that IIAEK significantly...

Topics

Open a Topic to create a Post that cites this publication.

• ATP Binding Cassette Transporter, Subfamily G, Member 1
• Benzoates
• Benzylamines
• Endosomes
• Intracellular Space
• Macrophages, Peritoneal
• Sterol Regulatory Element Binding Protein 2
• Sterols

Identifiers and source

Literature Corpus work

ece4e279-fab9-5c44-8d00-8df6faf5d2de

DOI

10.20944/preprints202008.0055.v1