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Article

Species-specific differences in agonistic activity of ago-allosteric modulators toward glucagon-like peptide 2 receptor.

Biomedical research (Tokyo, Japan) - 1 Dec 2012

Yamazaki Kazuto, Takase Kazuma, Watanabe Misako, Kagaya Takaki, Terauchi Hiroki, Iida Daisuke, Fukumoto Hironori, Suzuki Shuichi, Arai Tohru, Aoki Mika, Seiki Takashi, Tsukahara Kappei, Nagakawa Junichi

Abstract excerpt

Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP- 2R), a class-B G protein-coupled receptor (GPCR) coupled with Gα(s). Few small-molecule agonists had been reported for class-B GPCRs, but we recently reported the first scaffold compounds of ago-allosteric modulators for human GLP-2R. Methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-...

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PMID: 23268957
DOI: 10.2220/biomedres.33.337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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