Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening of autoinflammatory genes in patients with SARS-CoV-2-associated MIS-C.

Human genomics - 11 Jun 2026

São Pedro Raquel Bispo, Novaes Sâmek D, Barreto Thaís M M, Silva Andréia S, Nogueira Ana L, Bellinat Ana P N, Nunes Sara, Amaral Edson H B, Lessa Alana C M, Moreira Alberto O, de Jesus Thayse S, Mirabal Bernardo, Tiwari Sandeep, Castro Thiago L P, Tavares Natália M, Oliveira-Sá Marcus V B, Ramos Regina C F, Carmo Rodrigo F, Vasconcelos Luydson R S, Oliveira Pablo R S

Abstract excerpt

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication of SARS-CoV-2 infection, characterized by systemic hyperinflammation. Evidence indicates innate immunity defects may predispose children to MIS-C. Host genetics may influence MIS-C susceptibility and severity, but underlying mechanisms remain incompletely understood. The aim of this study was to identify rare...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM17 Protein
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CARD Signaling Adaptor Proteins

Share to COVID-19

Share to Exome Sequencing

Share to Molecular Docking Simulation

Share to SARS-CoV-2

Share to Systemic Inflammatory Response Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 42277935
DOI: 10.1186/s40246-026-00985-0
PMCID: PMC13480074

Genes

ADAM17
CARD14
NOTCH1
SH3BP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening of autoinflammatory genes in patients with SARS-CoV-2-associated MIS-C.PMID 42277935Read ↗

Rare Genetic Variants of NLRP12 in Admixed Latino-American Children With SARS-CoV-2-Related Multisystem Inflammatory Syndrome.Semantic proximity Read ↗

Genomic and phenotypic characterization of Multisystem Inflammatory Syndrome in Children (MIS-C): a prospective multicenter study from the Middle EastSemantic proximity Read ↗

MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunitySemantic proximity Read ↗

Genetic insights into MIS-C Post-COVID-19 in Kuwaiti children: investigating monogenic factors.Semantic proximity Read ↗

Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in ChildrenSemantic proximity Read ↗

Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort studySemantic proximity Read ↗

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C).Semantic proximity Read ↗

Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory SyndromeSemantic proximity Read ↗

Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in childrenSemantic proximity Read ↗

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).Semantic proximity Read ↗

Clinical Phenotypes and Outcomes in Children with Multisystem Inflammatory Syndrome Across Sars-CoV-2 Variant Eras: A Multinational Study from the 4CE ConsortiumSemantic proximity Read ↗

Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortiumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.