Back to search

Article

Ratio-Driven Lipoprotein Mapping Refines Genetic Pathways of Cardiometabolic Risk

2026-01-07

Abstract excerpt

<title>Abstract</title> <p>Dysregulated blood lipids are a major predictor of cardiovascular events. A recent genome-wide association study (GWAS) with five clinically relevant lipid traits in 1.65 million individuals implicated over 770 genomic regions in regulating blood lipid metabolism. To translate these associations into clinical applications, a functional understanding of their roles in lipoprotein metabol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ebb0ab6a-d461-5352-a782-1a47688737d8
DOI
10.21203/rs.3.rs-8475327/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ratio-Driven Lipoprotein Mapping Refines Genetic Pathways of Cardiometabolic RiskDOI 10.21203/rs.3.rs-8475327/v1
Lipoprotein profile and metabolic fine-mapping of genetic lipid risk lociSemantic proximity
(Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery DiseaseSemantic proximity
The Mediating Role of IDL Particles in the Relationship between Primary Hypertension and Cardiovascular Diseases: Insights from Mendelian Randomization and Multi-Omics AnalysisSemantic proximity
Size-Resolved Lipoprotein Fatty Acid Content as a Novel Nuclear Magnetic Resonance-Derived Trait Specifically Associates with Genetic Variants That Control Fatty Acid Metabolism.Semantic proximity
Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathwaysSemantic proximity
Relationship of Fat Mass Ratio, a Biomarker for Lipodystrophy, With Cardiometabolic TraitsSemantic proximity
Lipoprotein Subclass Profiling Reveals Pleiotropy in the Genetic Variants of Lipid Risk Factors for Coronary Heart DiseaseSemantic proximity
Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factorsSemantic proximity
Genetic Modulation of LDL-C and Triglyceride Response to Mediterranean-Style Diet: Whole-Exome Evidence with a Focus on Plasma Lipoprotein PathwaysSemantic proximity
Cardiovascular events in individuals with small/medium LDL particle discordanceSemantic proximity
Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation AnalysisSemantic proximity
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.Semantic proximity
Select a neighboring publication to make it the new centre.