Article

Understanding Myelodysplasia and Inflammation through the Lense of VEXAS Syndrome: A Review

2024-10-09

Abstract excerpt

VEXAS syndrome, a monogenic X-linked disorder resulting from mutations in the UBA1 gene, has emerged as a key model for unraveling the links between systemic inflammatory or autoimmune diseases (SIAD) and myelodysplastic syndromes (MDS). This syndrome is characterized by the presence of vacuoles, X-linked inheritance, autoinflammation and somatic mutation patterns, highlighting a unique intersection between geneti...

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Literature Corpus work: eafcc72c-2431-5060-ab8f-a4e0366fd5f9
DOI: 10.20944/preprints202410.0614.v1

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