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Article

Looking beyond VEXAS: Coexistence of undifferentiated systemic autoinflammatory disease and myelodysplastic syndrome.

Seminars in hematology - 1 Oct 2021

Oganesyan Artem, Hakobyan Yervand, Terrier Benjamin, Georgin-Lavialle Sophie, Mekinian Arsene

Abstract excerpt

It has been established that individuals with myelodysplastic syndromes (MDS) have a higher frequency of systemic inflammatory disorders. On the other hand, patients with autoimmune diseases are at increased risk of MDS development. Both diseases can be associated with various genetic lesions and share diverse pathogenetic mechanisms. Recently identified VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory,...

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PMID: 34802547
DOI: 10.1053/j.seminhematol.2021.10.003

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