Article

Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics Analysis

2023-09-15

Abstract excerpt

The SARS-CoV-2 pandemic has caused millions of deaths worldwide. The pathogenesis of COVID-19 is complex and the mechanisms associated with variable clinical manifestations including mild, moderate and severe diseases are not fully understood. We used an integrated approach combining host-pathogen protein-protein interaction data and viral-induced host gene expression data to understand pathogenesis and identify k...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eae7169c-a2c2-54e6-b5aa-d0ef7a655e91
DOI: 10.2139/ssrn.4569729

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics AnalysisDOI 10.2139/ssrn.4569729Read

Molecular signatures in the progression of COVID-19 severitySemantic proximity Read

Buffy Coat Transcriptomic Analysis Reveals Alterations in Host Cell Protein Synthesis and Cell Cycle in Severe COVID-19 PatientsSemantic proximity Read

COVID-19 severity is associated with immunopathology and multi-organ damageSemantic proximity Read

The current landscape of coronavirus-host protein–protein interactionsSemantic proximity Read

Transcriptomic Similarities and Differences in Host Response between SARS-CoV-2 and Other Viral InfectionsSemantic proximity Read

Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseSemantic proximity Read

Study of Progression of COVID-19 in Indian Population based on Transcriptomic ApproachSemantic proximity Read

In Silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditionsSemantic proximity Read

Uncovering the Pathophysiological Pattern of Expression from Integrated Analysis across Uniformly Processed RNA Sequencing COVID-19 DatasetsSemantic proximity Read

SARS-CoV-2 disrupts host gene networks: unveiling key hub genes as potential therapeutic targets for COVID-19 managementSemantic proximity Read

Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19Semantic proximity Read

Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cellsSemantic proximity Read