Article

PPI-Refractory GERD in Systemic Sclerosis Is Driven by Distinct Esophageal and Gastric Motility Abnormalities

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gastroesophageal reflux disease (GERD) is highly prevalent in systemic sclerosis (SSc) and frequently persists despite proton pump inhibitor (PPI) therapy. However, the mechanisms underlying PPI-refractory GERD in SSc remain incompletely understood. <h4>Methods</h4> We conducted a singlel7lcentre, retrospective study of adults with SSc who underwent ambulatory pH-multichann...

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Literature Corpus work: ead59b25-95de-5612-b35d-d2792a6be321
DOI: 10.64898/2026.04.13.26350585

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