Article
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.
Molecular neurodegeneration - 8 Jan 2018
Yun Seung Pil, Kim Donghoon, Kim Sangjune, Kim SangMin, Karuppagounder Senthilkumar S, Kwon Seung-Hwan, Lee Saebom, Kam Tae-In, Lee Suhyun, Ham Sangwoo, Park Jae Hong, Dawson Valina L, Dawson Ted M, Lee Yunjong, Ko Han Seok
Abstract excerpt
BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibility of nigrostriatal dopamine (DA) neurons in L444P GBA heterozygous knock-in (GBA +/L444P ) mice to...
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