Article

Deconvolution reveals compositional differences in high-grade serous ovarian cancer subtypes

2023-06-15

Abstract excerpt

Ovarian cancer is a deadly disease with few effective therapies. The most common form is high-grade serous ovarian cancer (HGSOC). Transcriptomic subtypes of HGSOC have shown promise in characterizing tumor heterogeneity and are associated with survival. Gene expression signatures for the subtypes suggest variation in stromal cell types in the tumor microenvironment (TME). Here, we characterize the TME composition...

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Literature Corpus work: ea987316-0dab-5425-9a83-1a889f8fe08e
DOI: 10.1101/2023.06.14.544991

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