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Single nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell type-specific gene regulatory variation

2020-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expression. We report 20 658 single nuclei chromatin accessibility profiles of ventral midbrain from two genetically and phenotypically distinct mouse strains. We distinguish ten cell types based...

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Literature Corpus work
ea846874-455f-524a-8e30-1b4fb3a7dc46
DOI
10.1101/2020.06.10.144626
Open publication

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Single nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell type-specific gene regulatory variationDOI 10.1101/2020.06.10.144626
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