Article

Lead (Pb) exposure alters neural cell fate in the developing human brain

2025-08-17

Abstract excerpt

The heavy metal lead (Pb) is a developmental neurotoxicant associated with cognitive and behavioral deficits, but the cellular mechanisms underlying these impairments remain unclear. Here we show that prenatal Pb exposure biases human radial glia fate, prolonging neurogenesis and suppressing astrogenesis. We used hiPSC-derived cortical organoids, primary human fetal tissue, and in vivo xenografts to demonstrate t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6bd44f03-a44f-57a4-9f3a-29f03a323e4f
DOI: 10.1101/2025.08.14.670354

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lead (Pb) exposure alters neural cell fate in the developing human brainDOI 10.1101/2025.08.14.670354Read

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampusSemantic proximity Read

Epigenetic modifications associated with pathophysiological effects of lead exposureSemantic proximity Read

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoidsSemantic proximity Read

On‐going consequences of in utero exposure of Pb: An epigenetic perspectiveSemantic proximity Read

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoidsSemantic proximity Read

Epigenetics of Early-Life Lead Exposure and Effects on Brain DevelopmentSemantic proximity Read

Early life exposure to lead (Pb) and changes in DNA methylation: relevance to Alzheimer’s diseaseSemantic proximity Read

Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic inputs by myelin vacuolation.Semantic proximity Read

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPsSemantic proximity Read

Benzo[a]pyrene-induced AHR activation in human ESCs primes premature neurogenesis in brain organoidsSemantic proximity Read

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem CellsSemantic proximity Read

Low Dose Lead Exposure Induces Alterations on Heterochromatin Hallmarks Persisting Through SH-SY5Y Cell DifferentiationSemantic proximity Read