Article

Probe Design for Simultaneous, Targeted Capture of Diverse Metagenomic Targets

2020-12-23

Abstract excerpt

The compounding challenges of low signal, high background, and uncertain targets plague many sequencing efforts, including monitoring potential zoonotic resevoirs. One solution has been targeted DNA capture, where probes are designed to hybridize with target sequences, enriching them relative to the background. We have developed the HUBDesign pipeline which makes use of sequence homology to design probes at multip...

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Literature Corpus work: ea3d8fe9-f314-5718-85a7-8e537bbcb5dd
DOI: 10.2139/ssrn.3754546

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