Article

CIROZ variants cause heterotaxy syndrome and is specifically expressed in Gastruloids

2026-04-15

Abstract excerpt

<title>Abstract</title> <p> Heterotaxy syndrome (HTX) is a rare disease caused by the disruption of left-right asymmetric development, and is often accompanied by congenital heart disease (CHD). However, the regulatory mechanism of breaking symmetry is still incompletely understood. Gastruloids can recapitulate the key characteristics of early embryogenesis, serving as a valuable in vitro model for studying left...

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Literature Corpus work: ea2705e4-5826-5a47-920c-47ee2ed4a238
DOI: 10.21203/rs.3.rs-9257021/v1

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