Article

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance

2021-01-20

Abstract excerpt

Nephrocystin (NPHP1) is a ciliary transition zone protein and its ablation causes nephronophthisis (NPHP) with partially penetrant retinal dystrophy. However, the precise requirements of NPHP1 in photoreceptors are not well understood. Here, we characterize retinal degeneration in a mouse model of NPHP1 and show that NPHP1 is required to prevent infiltration of inner segment plasma membrane proteins into the outer...

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Literature Corpus work: ea15c486-11cf-5928-ab67-241a3a1512c2
DOI: 10.1101/2021.01.20.427412

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