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Impact of misclassified defective proviruses on HIV reservoir measurements

13 Jul 2023

Abstract excerpt

Most proviruses persisting in people living with HIV (PWH) on antiretroviral therapy (ART) are defective. However, rarer intact proviruses almost always reinitiate viral rebound if ART stops. Therefore, assessing therapies to prevent viral rebound hinges on specifically quantifying intact proviruses. We evaluated the same samples from 10 male PWH on ART using the two-probe intact proviral DNA assay (IPDA) and...

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PMID: 37443365
DOI: 10.1038/s41467-023-39837-z

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