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Article

Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards

10 Jan 2012

Abstract excerpt

OBJECTIVE: We investigated the dynamics of HIV RNA and HIV DNA levels after the commencement of raltegravir-based antiretroviral therapy (ART) in primary (PHI) and chronically HIV-infected (CHI) individuals (the PINT study). DESIGN: We recruited 8 PHI and 8 CHI ART-naive individuals who commenced a 1-year combination regimen of Truvada and the integrase inhibitor raltegravir. METHODS: Nonlinear mixed effects...

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PMID: 22410637
DOI: 10.1097/qad.0b013e328350fb3c

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