Article

Macrophage activation drives ovarian failure and masculinization

2023-01-03

Abstract excerpt

In humans, premature ovarian insufficiency (POI) is caused by autoimmunity and genetic factors, such as mutation of BMP15, a key ovarian determining gene. The cellular mechanisms associated with ovarian failure caused by BMP15 mutation and immune contributions to the disorder are not understood. BMP15’s role in ovarian follicle development is conserved in vertebrates, including zebrafish. Using zebrafish, we estab...

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Literature Corpus work: e99dfbf1-a0e0-5154-9826-6e8cefe22856
DOI: 10.1101/2023.01.03.522645

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