Article

High WEE2-AS1 expression in CAF-derived small extracellular vesicles inhibits the Hippo pathway to facilitate colorectal cancer progression via promoting degradation of MOB1A

2022-02-22

Abstract excerpt

<h4>Background: </h4> Cancer-associated ﬁbroblasts (CAFs) are the most abundant stromal components in the tumor microenvironment (TME) and exert a critical effect on regulating tumor initiation and progression. However, the precise biological functions and underlying mechanisms of CAFs in the TME have yet to be understood. <h4>Methods: </h4>: CAFs and normal fibroblasts (NFs) were isolated from paired fresh CRC an...

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Literature Corpus work: e962698f-e700-5b4e-a622-623199aeb999
DOI: 10.21203/rs.3.rs-1360377/v1

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