Article

Islet primary cilia motility controls insulin secretion

2021-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here we show that primary cilia in pancreatic beta cells exhibit movement that is required for glucose-dependent insulin secretion. Beta cell cilia contain motor proteins conserved from those found in classic motile cilia, and...

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Identifiers and source

Literature Corpus work: e9520360-f53d-5545-a5ac-5306456209d3
DOI: 10.1101/2021.12.14.472629

Open publication

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